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Methadone is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatment options are inadequate. It’s recommended that use is reserved for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.
Methadone is also indicated for detoxification treatment of opioid addiction (heroin or other morphine-like drugs), and for maintenance substitution treatment for opioid dependence in adults in conjunction with appropriate social and medical services
Overall, methadone’s pharmacological actions result in analgesia, suppression of opioid withdrawal symptoms, sedation, miosis (through binding to receptors in the pupillary muscles), sweating, hypotension, bradycardia, nausea and vomiting (via binding within the chemoreceptor trigger zone), and constipation. Like many basic drugs, methadone also enters mast cells and releases histamine by a non-immunological mechanism leading to flushing, pruritus, and urticaria, which can commonly be misattributed to an allergic reaction.
guide on how to use methadone
The Victorian pharmacotherapy program uses the syrup form of methadone. There are 2 brands of this liquid: Methadone Syrup® and Biodone Forte®.Generally, there are 2 types of methadone programs:
- Maintenance (long-term programs): May last for months or years, and aim to reduce the harms associated with drug use and improve quality of life.
- Withdrawal (short-term detoxification programs): Run for approximately 5-14 days and aim to ease the discomfort of stopping the use of heroin.
For pain relief methadone is administered through an injection or tablets.
How effective is it?
Methadone treatment is more likely to be successful if it is part of a comprehensive treatment program, which addresses the body, mind and environment in which heroin has been used.