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about carfentanil

Carfentanil binds very strongly to mu opioid receptors and acts as a competitive agonist. Hence, binding of the opiate stimulates the exchange of GTP
for GDP on the G-protein complex.
How Does Carfentanil Affect Humans?
Because of carfentanil’s potency, the effects on the human body and brain are
very rapid. Even in elephants, the sedative effects are especially rapid. According
to Elephant Care International, veterinarians must watch elephants for signs of
pulmonary edema and capillary bleeding, characterized by a pink foam issuing
from the elephant’s trunk, which indicates a potentially fatal rise in blood pressure.
While doses administered to elephants are specifically to knock the animal
narcotics, Iike oxycodone or hydrocodone, given to humans to treat pain. When
even a fraction of the dose given to elephants is administered to humans, onset is
rapid, difficult to stop, and hard to treat.

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